The Complete Guide to Human Growth Hormone Supplements

Human growth hormone supplements are all the go nowadays.

According to the companies and ex-basketball stars that peddle them, they’re the answer to increased muscle growth and fat loss, child-like energy levels, and deep, restful sleep.

And if you’re like many folks, this sounds too good to be true. 

Is there really such a thing as a natural “HGH booster?” 

Is there any science behind these products?

And even if they work, are human growth hormone supplements safe?

Get an evidence-based answer in this article.

What Is Human Growth Hormone?

Human growth hormone (HGH), also known as somatropin or simply “growth hormone,” is a hormone produced by the pituitary gland.

HGH is responsible for regulating growth during childhood and adolescence, though it also figures prominently in fat burning and muscle growth.

Specifically, HGH causes fat “mobilization,” which means it helps your body release the fatty acids stored in fat cells, and it promotes the release of insulin-like growth factor 1 (IGF-1), which triggers muscle growth, blunts muscle breakdown, and further encourages fat mobilization.

What Are Human Growth Hormone Supplements?

Human growth hormone supplements are dietary supplements that contain ingredients purported to increase your body’s HGH levels.

For example, research shows that using human growth hormone for bodybuilding can hinder heart health, cause insulin resistance, and increase your risk of blood, breast, colon, prostate, and endometrial cancer. 

Human Growth Hormone Supplements: Benefits

Lysine

Lysine, or L-lysine, is an essential amino acid (an amino acid your body must obtain through your diet) that plays a part in muscle protein synthesis and cellular function.

Research shows that supplementing with lysine alone doesn’t boost HGH levels. 

While some research shows that combining lysine with the amino acid arginine may increase HGH levels, other studies show the increase is too small to make any meaningful difference to body composition.

Therefore, there’s little evidence that supplementing with lysine increases HGH levels to a significant degree.

Arginine

Arginine, or L-arginine, is an amino acid that your body uses to synthesize nitric oxide, a substance that relaxes your blood vessels, regulates blood flow, and improves athletic performance.

Similarly to lysine, taking arginine alone doesn’t boost HGH. This may change when combined with lysine, but this evidence is inconclusive.

One study published in The Journal of Sports Medicine and Physical Fitness showed that combining arginine with the amino acid ornithine significantly increased HGH levels in men who also followed a weightlifting program.

There are two problems with this study, though.

First, several studies show that strength training alone increases HGH levels. As such, it’s impossible to know whether the participants experienced increased HGH because of the supplement or because they lifted weights.

Second, subsequent research has called into question the methods the scientists used. For example, the authors measured the participants’ weight using a spring scale, their body fat percentage using calipers, and their body fat mass using a tape measure, which are all prone to significant error.

Another study published in the Journal of Strength and Conditioning Research found that men who supplemented with arginine and ornithine had higher HGH levels than men who took a placebo after completing a weightlifting workout.

The same problem persists, however: The participants took two supplements, making it impossible to know which was responsible for the increase in HGH. What’s more, studies using similar supplement combinations have failed to replicate the results.

At bottom, there’s almost no reason to believe arginine affects HGH levels.

Ornithine

Ornithine is an amino acid that’s involved in the urea cycle, a process that balances out urea and ammonia levels in the body.

As we’ve already seen, studies looking at the effect of taking ornithine and arginine on HGH are inconclusive. Similar research shows that taking ornithine in combination with tyrosine doesn’t raise HGH levels, either.

Results from studies investigating how ornithine alone affects HGH show that taking large doses may increase HGH for a short time. Although this result seems encouraging, there are two caveats.

First, to raise HGH levels, you have to take an impractically large dose of ornithine that’s highly likely to cause severe stomach cramps and diarrhea.

Second, these studies only consider HGH changes over 90 minutes. For growth hormone to have an appreciable effect on muscle building and fat loss, it needs to be elevated for far longer (days or even weeks).

Taken together, there’s little evidence that ornithine meaningfully increases HGH levels.

Glutamine

Glutamine is the most abundant and versatile amino acid in the body.

Most research looking at glutamine’s effect on HGH levels is conflicting, with some studies showing taking glutamine increases HGH (at least for a short while) and others demonstrating the opposite (even after weightlifting).

In one notable study conducted by scientists at the Pennington Biomedical Research Center, researchers found that taking a supplement containing glutamine (as well as lysine, arginine, and several other ingredients) increased HGH levels by 682% after just 2 hours. 

(The same lab released a subsequent paper detailing the mechanisms behind this staggering result.)

While these results seem promising, the scientists who conducted the study work for the company that makes the supplement they used. Thus, it’s probably sensible to be chary of these findings until a disinterested third party replicates them (which hasn’t yet happened).

Gamma Aminobutyric Acid (GABA)

Gamma-aminobutyric acid (GABA) is a special type of amino acid that acts as an “inhibitory” neurotransmitter, which means it prevents chemical messages from being passed from neuron to neuron.

It also plays a key role in reducing stress and inducing sleep.

While research shows that taking GABA post exercise can increase HGH levels, the increases are too tiny and temporary to affect body composition.

Deer Antler Velvet

Deer antler velvet is the soft hair that covers a deer’s (or elk’s) antlers that’s been used in traditional Chinese medicine for millennia.

To make deer antler velvet supplements, supplement companies remove a deer’s antlers, then strip, dry, and grind the velvet into a powder. The powder is then packed into pills or dissolved in liquid, ready for ingestion.

Deer antler velvet contains IGF-1. Since HGH and IGF-1 are closely related, many people think that taking deer antler velvet may boost HGH.

However, there’s no evidence that supplementing with deer antler velvet increases IGF-1 or HGH.

Mucuna Pruriens

Mucuna pruriens, also commonly known as velvet bean and cowhage, is a climbing shrub in the legume family that’s native to Africa and Asia and cultivated in North America. It produces hair-covered seeds that cause intense itching if they touch your skin.

These seeds contain levodopa (L-DOPA), which is an amino acid involved in the production of dopamine, a neurotransmitter that regulates your mood, cognition, and motivation to exercise.

While older research suggests supplementing with L-DOPA may increase HGH, there’s no evidence the increase is large or lasting enough to benefit body composition. 

What’s more, there’s little reason to believe that taking Mucuna pruriens has a similar effect.

The only evidence comes from a study conducted by scientists at the University of Memphis, in which participants experienced an increase in HGH after taking a supplement containing Mucuna pruriens and safed musli.

Given that the supplement contained two ingredients, the participants exercised regularly (although not within 48 hours of the study), and a supplement company that sells the supplement used in the study funded the research, it’s difficult to know how reliable these results are.

Thus, there’s no strong evidence that Mucuna pruriens boosts HGH.

Astragalus

Astragalus is a herb used in traditional Asian medicine, most often as a tonic or diuretic. 

Some research on rats and rat cells suggests that astragalus may increase HGH secretion, but there’s no evidence that the same is true in humans. 

Until we have more compelling research, it’s safe to conclude that astragalus doesn’t increase HGH.

Human Growth Hormone Supplements: Side Effects

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• Lysine: Common side effects associated with taking large doses of lysine include nausea, vomiting, abdominal pain, diarrhea, skin rash, dizziness, and headache.
• Arginine: Arginine is generally considered safe, though some who take it may experience gastrointestinal upset.
• Ornithine: Taking large doses of ornithine can cause severe stomach cramps and diarrhea.
• Glutamine: Short-term glutamine use isn’t associated with any adverse side effects, though some research suggests long-term usage may negatively affect health in numerous ways, including compromising immune function, increasing cancer risk, and impairing gut and kidney health.

• GABA: Most studies suggest GABA is well-tolerated. That said, some people report feeling a burning sensation on the throat, breathlessness, lethargy, and weakness in the legs following GABA ingestion.

• Deer Antler Velvet: There are no known side effects associated with taking deer antler velvet.
• Mucuna Pruriens: Most people don’t experience negative side effects from taking Mucuna pruriens. However, because Mucuna pruriens contains L-DOPA, it can have the same side effects as levodopa, which include nausea, vomiting, anxiety, low blood pressure, and dyskinesia (involuntary muscle movements).
• Astragalus: Supplementing with astragalus may cause rash, itching, nasal symptoms, or stomach discomfort, but these are uncommon.

Conclusion

Research routinely shows that intense weightlifting and lowering your body fat percentage increase HGH more than any legal supplement ever will. 

And if you want an exercise program that includes plenty of heavy lifting and a diet plan designed to help you lose fat like clockwork, check out my fitness books for men and women, Bigger Leaner Stronger and Thinner Leaner Stronger. 

(Or if you’re not sure if Bigger Leaner Stronger or Thinner Leaner Stronger is right for you, take the Legion Strength Training Quiz, and in less than a minute, you’ll know the perfect strength training program for you. Click here to check it out.)